Initially identified for its role in neurogenesis and brain size regulation, ASPM is frequently overexpressed in various cancers, including pancreatic ductal adenocarcinoma, gastric cancer, small cell lung cancer, kidney renal clear cell carcinoma, liver hepatocellular carcinoma, and gliomas [79,80,81], and is also associated with increased proliferation, angiogenesis, metastasis, and drug resistance [80,81,82]. Here, ASPM is linked to pancreatic ductal adenocarcinoma.