Three of the leading genome regions associated with ME/CFS harbour gene members of the NBPF, namely NBPF1, NBPF10, and NBPF16. As indicated by several reports, the NBPF is a cluster of genes spanning disparate regions of human chromosome 1 and was generated by duplications in primate evolution. Here, NBPF15 is linked to myalgic encephalomeyelitis/chronic fatigue syndrome.