INS and hypertensive disorder: There are many factors that affect miR-192 expression, including chronic medical conditions such as hypertension, medications like metformin, angiotensin-converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs), and insulin [28] Additionally, physical activity may affect miR-192 expression [29] Most other studies overcame these factors that may affect miR-192 expression.