Other risk factors listed in the literature, like systemic hypertension, major surgery, estrogen therapy, pregnancy and post-partum states, various medications (dopamine receptor agonist, isosorbide, chlorpromazine, GnRH agonist, and clomiphene), radiation therapy, head trauma, pituitary surgery, and gamma knife therapy, can be easily excluded in this case [29]. This evidence concerns the gene GNRH1 and Hypertension.