Possible outcomes of this CFNBS include false positives, healthy carriers, CF diagnoses, and children who screen positive but who do not have a conclusive diagnosis, termed “CF screen-positive inconclusive diagnosis” (CFSPID) in Europe or “CFTR-Related Metabolic Syndrome”(CRMS) in the United States [5]. Here, CFTR is linked to CFTR-related metabolic syndrome/CF screen positive, inconclusive diagnosis.