CFTR and cystic fibrosis: Tosco et al. studied a cohort of 27 individuals with 5T12TG/VVCC and reported eight diagnoses of CFTR-RD based on their CF family history (50%), respiratory symptoms (25%), recurrent pancreatitis (12.5%), and CBAVD (12.5%), and one was diagnosed with CF from the outset due to bronchiectasis and CBAVD with a positive SC result; this corresponds to 33.3% symptomatic people in the cohort) [20].