CDKN1A and retinal disorder: The detection of pathognomonic signatures associated with cellular senescence, including upregulated cell cycle checkpoint regulators (p53, p16INK4a, and Cdkn1a/p21^CIP/WAF1) along with stress response mediators (PAI-1 and PML nuclear bodies), correlates with the accumulation of senescent cell populations across multiple retinopathy subtypes [122].