Previous studies showed in the skeletal muscle of cocaine-exposed eels signs of injury such as muscle breakdown and swelling, reminiscent of rhabdomyolysis, and these more evident in slow fibers; there was an increase in caspase-3 activity, and of serum levels of creatine kinase, lactate dehydrogenase, and aspartate aminotransferase, markers of the functional state of the muscle [80]. Here, CASP3 is linked to rhabdomyolysis.