Seeing that no significant changes were detected related to Il-1β and Il-6, and given that the gene expression of Iba1 and Tnfα in the A53T+ mice was influenced by housing conditions while the behavioral outcomes were not, as well as the fact that the differences were not evident in comparison to A53T−, we speculate that the observed changes in gene expression may not be directly linked to the observed cognitive deficits in the A53T+ mice. The gene discussed is TNF; the disease is Cognitive impairment.