Glucose: ↑; insulin: ↔; glucose intolerance: ↑; femur length: ↓; BMD: ↓; BMC: ↓; OCN: ↓; TRAP: ↓; force: ↓; stiffness: ↔; work to failure: ↔; stress: ↔; elastic modulus: ↓; toughness: ↓Cortical parameters:Ct.Ar: ↓; Ct.Th: ↔Trabecular parameters:Tb.Ar: ↔. The gene discussed is INS; the disease is Glucose intolerance.