Fasting glucose: ↑; fasting insulin: ↑; glucose intolerance: ↑; leptin: ↑; tibia length: ↓; whole body BMD: ↓; Runx2: ↓; COL1: ↓Cortical parameters:Ct.Th: ↔; Ct.Ar: ↔Trabecular parameters:BV/TV: ↓. The gene discussed is INS; the disease is Glucose intolerance.