HSF1 and neoplasm: For example, ATF2 is involved in stress response and apoptosis, WT1 in anti-apoptotic signaling, and TEAD1 in mechanotransduction and survival in stiff tumor environments; HSF1 is a key regulator of the heat shock response for survival under stress, HIF-1A is a master regulator of hypoxia responses, NR1H4 mediates metabolic detoxification and oxidative stress resistance, OCT1 regulates genes involved in oxidative stress adaptation and hypoxia, and TP53 is a guardian of genomic stability and oxidative stress response.