In the context of the safety and necessity of applying SGLT2ins and GLP-1 RAs in older populations with T2D, apart from their well-known beneficial effects on cardiovascular and renal protection, a recent study brought new insights into their positive influence in reducing the risk of Alzheimer’s disease and related dementias [35]. The gene discussed is GLP1R; the disease is early-onset autosomal dominant Alzheimer disease.