The pathogenesis of membranous nephropathy (MN) is intricately associated with the dysregulated expression of core regulatory genes including MYO9A, NFKBIZ, RTTN, and USP40, which collectively demonstrate multidimensional clinical relevance spanning disease progression monitoring, prognostic stratification, and therapeutic target development. Here, NFKBIZ is linked to membranous glomerulonephritis.