In HCC, the depletion of overexpressed KDM2A coincides with the reduced presence of H3K36me2 in the promoter region of genes and leads to the re-expression of innate and adaptive immunity proteins such as PD-L1 in human HCC cells and H2-D1, H2-T23, and Mr1 in the HCC of mice. The gene discussed is MR1; the disease is hepatocellular carcinoma.