HIF1A and Hepatic fibrosis: Similarly, a recent study showed that hypoxia aggravates liver fibrosis through the upregulation of HIF-1α and interleukin-6 (IL-6) in human fibrotic tissues, a CCl4-induced mouse model (C57BL/6J), and a human stellate cell line (LX-2), where IL-6-mediated IL-17A secretion exacerbated disease progression [10].