In patients with acute promyelocytic leukemia (APL or AML-M3) treated with all-trans retinoic acid (ATRA) that induces IFIT3 expression, high IFIT3 expression levels in peripheral blood were found to be associated with remission, while a relapse was associated with IFIT3 expression levels returning to lower levels, as observed before treatment [88]. This evidence concerns the gene IFIT3 and acute myeloid leukemia.