These tumor suppressive effects of IFIT2 in CRC have been proposed to be regulated by a blockage of its degradation by inhibition of proteasome activity and subsequent aggregation of IFIT2 in the centrosome [53] and suppression of the JAK1/STAT/IFIT2 network by the Ajuba scaffold protein [54]. This evidence concerns the gene IFIT2 and colorectal carcinoma.