Dickkopf-3 (DKK-3) is a urinary glycoprotein secreted as a response to stress and is expressed in tubular cells after injury [80], serving as a marker for ongoing tubular stress with the potential of serving as a biomarker of CKD progression; currently, several studies have confirmed its potential as an ongoing biomarker of renal injury [81]. The gene discussed is DKK3; the disease is chronic kidney disease.