A systematic search of the PubMed/Scopus databases (2020–2025) was conducted using the keywords MAFLD, NAFLD, transcription factor, gut–liver axis, metabolism, lipogenesis, steatosis, inflammation, fibrosis, immune signaling, microbiota, therapeutics, some specific metabolites, and TFs (e.g., PPAR, FXR). The gene discussed is NR1H4; the disease is steatosis.