The cyclic peptide LyP-1 (CGNKRTRGC) targets the protein p32 (also known as gC1qR or HABP1), which is upregulated on the surface of various tumor cells (e.g., breast cancer, osteosarcoma), tumor-associated macrophages, and tumor lymphatic vessels, particularly under conditions of cellular stress such as hypoxia or heat treatment [57]. This evidence concerns the gene PTPN22 and osteosarcoma.