The risk stratification was based on the subject’s MRD status, age, white blood cell count, CNS status, DNA index, ALL subtype, hyperdiploidy, hypodiploidy, TEL/AML status, MLL translocations, Philadelphia (Ph) chromosome, t(1;19) translocation, and additional chromosomal abnormalities. This evidence concerns the gene KMT2A and acute lymphoblastic leukemia.