The benefits of S1R agonism following stroke are not limited to motor recovery but also suggest cognitive improvement in post-stroke models when treated with the S1R agonists ulinastatin, oxeladin, and PRE-084 by rescuing BDNF through the NR2A-CaMKIV-TORC1 pathway [52,61,62,63]. The gene discussed is BDNF; the disease is Stroke.