TMBIM4 and amyotrophic lateral sclerosis: Notably, a common selective serotonin reuptake inhibitor (SSRI), fluvoxamine, possesses S1R agonism and has been shown to restore autophagic balance in inherited ALS by stabilizing nucleoporin complexes with Pom121 protein expression and localizing the autophagy factor TFEB to the nucleus [143].