In order to identify immunological markers associated with cardiovascular diseases in elderly patients, in comparison with healthy elderly people, we studied an extended panel of immunological parameters, including links of both innate (monocytes, natural killers, and activation markers) and adaptive immunity (regulatory T-lymphocytes CD4+ and CD8+), as well as the intracellular production of pro- and anti-inflammatory cytokines and growth factors. The gene discussed is CD4; the disease is cardiovascular disorder.