ELOVL2 and endothelial dysfunction: The observed alterations in lipid metabolism can be attributed to the upregulation of stearoyl-CoA desaturase-1 (SCD1) and the impairment of FADS1/2 and ELOVL2/5 activity, which in turn give rise to conditions conducive to inflammation, endothelial dysfunction, and plaque instability [52,59,60].