PLOD2 and biliary tract cancer: For instance, hypoxia-induced procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2) impairs chemoresistance through EMT and is associated with poor prognosis and increased LNM, which is a significant unfavorable prognostic factor for predicting recurrence-free survival and OS in biliary tract cancer [29].