For instance, knockdown of HIF-1α significantly reverses hypoxia-induced migration and downregulates the expression level of VEGFs in GBC, while the overexpression of HIF-1α is associated with LNM, suggesting HIF-1α may contribute to tumor migration via the HIF-1α/VEGF signaling pathway in GBC [27,28]. This evidence concerns the gene VEGFA and neoplasm.