Recently, Chen’s team found C-C motif chemokine ligand 2 (CCL2) bonded to CCR2 on tumor cells and activated the mitogen-activated protein kinase (MEK)–extracellular signal-regulated kinase (ERK)–ELK1 axis, which was found to correlate with LNM, leading to increased EMT induction and stemness of GBC in murine models [22]. Here, CCL2 is linked to neoplasm.