CDH2 and cholangiocarcinoma: On one hand, LINC01503 [49], LINC00667 [50], LINC00261 [51], H19 [52], and PCAT1 [53] directly downregulate the epithelial marker E-cadherin while upregulating mesenchymal markers N-cadherin and Vimentin, promoting EMT progression in CCA cells.