CCR7 and hilar cholangiocarcinoma: Furthermore, Oba et al. analyzed immunohistochemical (IHC) staining of C-C chemokine receptor 7 (CCR7) in 181 patients with perihilar cholangiocarcinoma and found that CCR7 expression was significantly correlated with the mesenchymal cell phenotype and facilitated migration and invasion of extrahepatic cholangiocarcinoma cells by inducing EMT [13].