The use of PD-L1 (+) small EVs concentration in plasma as a prognostic factor in patients with non-small cell lung cancer (NSCLC) was investigated by Eslami-S et al. Increase in PD-L1 (+) small EVs concentration was significantly associated with worse overall survival in NSCLC patients (HR increase of 5pg/mL = 1.14, 95% CI = 1.03–1.26, p = 0.016). Here, CD274 is linked to non-small cell lung carcinoma.