Importantly, qRT-PCR analysis showed an up-regulation of several potential SASPs factors, including TNF-α, IL-1β, IL-6, IL-15, CCL2, CCL3, and GDF15, in the muscle tissue of fractured patients, suggesting an association between osteoporosis and a muscle microenvironment characterized by increased inflammation and structural degradation processes. This evidence concerns the gene GDF15 and osteoporosis.