CD4 and Alzheimer disease: Quantitative deconvolution of 28 immune subtypes revealed significant intergroup disparities in 21 cell populations (p < 0.05), with AD specimens demonstrating marked elevation in 20 subtypes-including multiple CD8+ T lymphocyte subsets (activated, central memory, effector memory), Th1/Th2/Th17/Tfh polarized CD4+ cells, and innate immune effectors (macrophages, neutrophils, dendritic cell subsets) (Figure 8A).