IGHE and asthma: This complex immunopathology gives rise to diverse asthma phenotypes and endotypes, including allergic asthma (early-onset, IgE-mediated); eosinophilic asthma (often steroid-responsive); neutrophilic asthma (frequently steroid-resistant); and paucigranulocytic asthma (minimal inflammation but marked airway hyperreactivity) [10,11].