MAPT and early-onset autosomal dominant Alzheimer disease: Alzheimer’s disease: Plaques of amyloid beta and neurofibrils of tau protein (the classic markers of Alzheimer’s disease in the brain) have been demonstrated in the retina of patients affected by Alzheimer’s disease, suggesting that these dysfunctions could explain the pathogenesis of Alzheimer’s-associated retinal degeneration, a phenomenon characterized, in particular, by thinning of the retinal nerve fiber layer and loss of RGC [33,34].