Therefore, this inspires us to explore the carcinogenic effects of RPLP2 in DLBCL, investigate the specific role of the RPLP2-FXN axis in the regulation of ferroptosis in DLBCL for the first time, and further illustrate the possibility of targeting RPLP2 to improve therapeutic efficacy in DLBCL. Here, RPLP2 is linked to diffuse large B-cell lymphoma.