IDH-wildtype glioblastoma is associated with poor prognosis (median survival of 14 months) and PTEN, TP53, TERT, EGFR, and PIK3R1 mutations, as shown in Figure 2 [11,31,39,49,50,60,61,75,83,85,99,100,104,117,118,119,121]. The gene discussed is IDH2; the disease is glioblastoma.