It has been observed that tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs) are often recruited to the tumor site, where they release immunosuppressive cytokines, such as IL-10 and transforming growth factor-beta (TGF-β), which inhibit the activity of cytotoxic T cells and natural killer (NK) cells [17]. The gene discussed is TGFB1; the disease is neoplasm.