Xu et al. suggest that TGF-β1 is involved in the formation of intracranial aneurysms, as its elevated levels—mediated by hypoxia-inducible factor 1-antisense RNA 1 (HIF1A-AS1)—may inhibit the proliferation of vascular smooth muscle cells [38]. This evidence concerns the gene TGFB1 and Dilatation of the cerebral artery.