Therefore, to gain a deeper insight into the role of TGF-β factors in the formation and rupture of IA, we evaluated the gene expression of all three transforming growth factors (TGFB1, TGFB2, TGFB3) in peripheral blood mononuclear cells (PBMCs) isolated from the blood of patients with unruptured intracranial aneurysms (UIAs) and ruptured intracranial aneurysms (RIAs), comparing these findings with a control group. Here, TGFB3 is linked to Dilatation of the cerebral artery.