Several studies have linked the overactivation of the TGF-β pathway and mutations in the TGFB3 ligand to significant involvement in cardiovascular conditions, including thoracic and abdominal aortic aneurysms, as observed in syndromes such as Marfan and Loeys–Dietz, as well as in arterial dissection and mitral valve disease [42,43,44,45,46]. This evidence concerns the gene TGFB1 and mitral valve disorder.