Dysbiosis of the gut microbiota, which is defined by an imbalance between beneficial and opportunistic microbial populations, has been linked to IBD [36].The gut microbiota and the host participate in various mechanisms of reciprocal regulation, one critical mechanism is the cGAS/STING pathway, which plays a vital role in the recognition of exogenous DNA, including bacterial double-stranded DNA; this recognition subsequently activates the innate immune defense response, leading to the activation of the NF-κB pathway and regulation of the secretion of type I interferons [37]. The gene discussed is NFKB1; the disease is inflammatory bowel disease.