Lipid metabolism disorders: Additional research in murine atherosclerosis models and ox-LDL-treated macrophages has revealed that knocking down lncRNA GAS5 boosts miR-135a, thereby attenuating atherogenic lipoprotein fractions and pro-inflammatory mediators (IL-1β, IL-6, TNF-α), while elevating high-density lipoprotein cholesterol (HDL-C). This evidence concerns the gene GAS5 and atherosclerosis.