Cardiovascular disease: GAS5 plays a significant role in the cardiovascular system, participating in hypertension-induced vascular remodeling, cardiomyocyte apoptosis, and the regulation of apoptosis and proliferation in VSMCs by modulating β-catenin signaling (associated with vascular remodeling) [48], sema3a (linked to cardiomyocyte apoptosis) [52], and interacting with YBX1 and miR-21 (related to VSMC apoptosis) [45]. The gene discussed is GAS5; the disease is cardiovascular disorder.