RARA and acute promyelocytic leukemia: In acute promyelocytic leukemia (APL), the t(15;17)(q24;q21) translocation-generated PML-RARα fusion transcripts drive leukemogenesis [33], where the chimeric protein recruits corepressors (NCoR/SMRT) and histone deacetylases to repress RARα-mediated transcription, thereby blocking myeloid differentiation [34].