Liver disease: Wang et al. [124] showed that a tumor necrosis factor-induced toxic liver injury (LPS model) occurred because of the JNK2-, but not JNK1-, dependent activation of caspase-8 and the mitochondrial death pathway, i.e., JNK2-KO mice were protected from LPS-mediated liver injury. The gene discussed is MAPK8; the disease is liver disorder.