In this context, genome-wide association and case–control studies have revealed that the presence of polymorphic sites in the transcriptional repressor GATA binding 1 (rs231150 A/T and rs2737229 A/C) and tribbles pseudokinase 1 (rs2980880 T/C and rs2954029 T/A) genes are associated with a predisposition to CAD and with plasma lipid profile levels. This evidence concerns the gene TRIB1 and coronary artery disorder.