CD8A and neoplasm: We now know that IR can lead to immunogenic cell death, leading to the activation of dendritic cells, effector T cell priming, the recruitment of cytotoxic CD8 and Th1 cells [64], and the upregulation of cell adhesion molecules such as intracellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VACM)-1, leading to lymphocyte adhesion to the tumor vascular endothelium [65].