As a consequence, sleep disruptions exacerbate memory deficits and impair memory consolidation by facilitating neuroinflammation and altering glial polarizations to the proinflammatory state, reducing amyloid-β (Aβ) clearance, increasing tau hyperphosphorylation, and accelerating the neuronal apoptosis; all of which lead to neurodegeneration and ultimately AD. The gene discussed is MAPT; the disease is Alzheimer disease.