TNF and Cerebellar atrophy: In anti-Ri syndrome, the most promising treatments include: Lymphocyte depletion (Rituximab, Ocrelizumab) to reduce antibody production, Cytokine inhibition (Tocilizumab, anti-TNF) to limit neuronal damage, Neuroprotection (Ibudilast, Minocycline) to prevent cerebellar atrophy, Cell-based therapies (CAR-T, stem cells) as future prospects.