PKM and renal fibrosis: Pericyte pyruvate kinase M2 (PKM2) regulates pericyte glycolysis downstream of LDHA and GLUT1 transcription as well as lactate production, and the application of PKM2 nuclear translocation inhibitors (Shikonin and TEPP-46) modulates renal fibrosis by decreasing the extent of pericyte–myofibroblast transformation [78].