In addition to the canonical p.Met41 substitutions, at least six novel somatic UBA1 missense mutations—p.His55Tyr, p.Gly477Ala, p.Ala478Ser, p.Asp506Gly, p.Asp506Asn, and p.Ser621Cys—have been identified in VEXAS patients [5]. This evidence concerns the gene UBA1 and VEXAS syndrome.