EVs are also able to transport key factors in the body, such as APP, β-site APP cleaving enzyme 1, γ-secretase and their pyrolysis products, soluble APP β, soluble APP α, CCAAT box-binding transcription factors (CTFs), and Aβ [180], while APP-related metabolites may accumulate in exosomes under AD pathogenic conditions, contributing to disease progression [181]. This evidence concerns the gene APP and Alzheimer disease.