Therefore, we hypothesized that the high-MSLN-induced upregulated IL-6 axis (MSLNHIL6H) is an example of major survival/proliferation signaling in supporting PDAC cell growth; on the contrary, low-MSLN or MSLN-inhibition-induced upregulated IL-6 secretion (MSLNLIL6H) from senescent cells may play an important role in suppressing tumor progression. This evidence concerns the gene MSLN and neoplasm.