An extensive IHC workup was performed and was unrevealing with negative staining for carcinoma (CAM5.2, pancytokeratin, CK7, CK20), melanoma (S100, SOX10, HMB-45, Melan-A), hematolymphoid markers (CD45, CD43, CD3, CD20, CD30, CD4), myeloid markers (CD34, CD117), myoid markers (SMA, desmin), neuroendocrine markers (CD56, synaptophysin, chromogranin, NSE), pDC markers (CD123, CD303), histiocytic markers (CD68, CD163, CD1a, langerin), and follicular dendritic cell marker (CD21). This evidence concerns the gene TNFRSF8 and melanoma.