DCLK1-positive tuft cells, through the secretion of cytokines such as IL-25, activate group 2 innate lymphoid cells (ILC2s) to promote IL-4 and IL-13 release, which in turn drives macrophages toward an M2-like phenotype that favors tissue repair but also fosters immunosuppression and tumor progression [30,189]. The gene discussed is DCLK1; the disease is neoplasm.