DCLK1 and Axenfeld-Rieger syndrome: Recent work shows that DCLK1-expressing tuft cells play a critical role in post-irradiation repair; in mice, a single 12 Gy total-body dose leads to robust Dclk1 upregulation in surviving crypts, activation of DNA-damage and antioxidant pathways, and improved epithelial regeneration—effects that mitigate GI-ARS severity [48].