In further experiments, aimed at studying potential compounds capable of blocking the mechanism by which anticancer drugs are moved out of resistant tumor cells, MDCK cells and the variant expressing the human ABCB1 protein (MDCK-MDR1) were used to study the activity of isobavachalcone, a plant-derived molecule that has shown antiproliferative activity on several tumor cell lines [38]. Here, ABCB1 is linked to neoplasm.