The canine mammary cancer cell line B-CMT established from a primary mammary adenocarcinoma diagnosed in a female dog, has been described as a triple-negative cell line that overexpresses hypoxia inducible factor-1α (HIF-1α), leading to doxorubicin resistance by the inhibition of apoptosis and P-gp overexpression. The gene discussed is HIF1A; the disease is breast adenocarcinoma.