The average percentage of Foxp3-positive cells in the total cell counts was a median of 8.3 ± 4.6% in 72 cases, and the percentage of Foxp3-positive cells identified in or around the tumor cells was significantly higher in the three or more vaccination group (Figure 3e) and in the group with high serum IgG4 levels (Figure 3f). Here, FOXP3 is linked to neoplasm.