Figure 2A,B demonstrate that stimulation of LSECs with conditioned media derived from SW620 cancer stem cells (SW620-CSC) leads to a marked overexpression of genes predominantly located on chromosomes 1 and 12. Notably, as shown in Figure 2C,D, among the genes located on chromosome 1, PCSK9 is of particular interest as it is significantly upregulated and ranks among the top 50 most overexpressed genes in LSECs following stimulation with SW620-CSC conditioned media. The gene discussed is PCSK9; the disease is cancer.